RA Capital

Platform for targeting previously 'undruggable' intrinsically disordered proteins

Small molecule AMPK activator for metabolic and cardiovascular disease

Faster and more accurate DNA synthesis using enzymes

Off-the-shelf natural killer cell therapies for B-cell malignancies and other cancers

Cis‑targeted cytokine platform to create highly selective cancer therapies

Extracellular protein degrader platform to treat a broad range of diseases

Engineered B-cell platform to create durable cellular immunotherapies

Targeting the tumor microenvironment with immunomodulatory biologics

Small molecule drugs for obesity and other metabolic diseases

Rationally designed cytokine therapies for cancer and autoimmune disease

Therapies modulating mitochondrial biology to address a wide range of diseases

A platform for creating in vivo-engineered cell therapies in oncology and inflammatory disease

Helping internally incubated companies conduct preclinical studies and build clinical strategies

Tumor-targeting antibodies that engage the patient's immune system for treating cancer

Small molecule therapies targeting key signaling pathways that drive multiple types of cancer

Direct-to-brain delivery platform to improve treatment of refractory neurologic diseases

Rapid EEG that increases accessibility, efficiency, and cost-effectiveness

Reformulated vasodilator for systemic sclerosis and PCSK9 antisense for cardiovascular disease

Recombinant human hepatocyte growth factor for treating corneal diseases

Comprehensive and all-inclusive orthopedic care services

First-in-class alpha-emitting radiobiologic in prostate cancer

Value-based autism care provider pioneering whole-child therapy

Vaccines to prevent shingles in older adults and chickenpox in immunocompromised children

Neuroplasticity-promoting therapies for neurologic diseases

Platform to rapidly discover agonist antibodies for a wide range of receptors

Therapies to restore voluntary bladder and bowel control lost due to neurologic impairments

Antibody targeting a key regulatory protein to treat immunologic diseases and cancer

High-performing and cost-effective benchtop DNA sequencing platform

Monitoring human health through wearable sensors linked with AI-powered systems

TCR-directed T-cell therapies targeting cancer-specific antigens

Engineered mRNA treatments that modulate cellular responses to mRNA to improve its therapeutic effect

Point-of-care ultrasound imaging device and workflow solutions

Small molecule therapies to treat myotonic dystrophy and other RNA-mediated diseases

Precision medicines using cyclic peptides against difficult-to-target disease proteins

Next-generation small molecule oral therapies for chronic immunological and inflammatory disorders

Multiomics blood tests for early detection of colorectal cancer and other cancers

Proteomics platform with integrated machine learning to create cancer therapies

Engineered regulatory T cells for immune-mediated and inflammatory diseases

Antibodies to promote blood clotting to treat bleeding and clotting disorders

Covalent inhibitors targeting non-cysteine amino acids to inhibit previously “undruggable” proteins

Therapies to correct cellular energy balance to treat cardiovascular disease and rare disease

Off-the-shelf cell therapies for cancer leveraging a subset of potent natural killer cells

Gene delivery platform to create in vivo CAR-T cell therapies for cancer

Therapies to normalize toxic metabolite levels to treat metabolic disorders

Small molecule eye-drop that restores near vision in patients with presbyopia

Gene therapies that restore normal RNA levels in repeat expansion disorders

Targeted radiopharmaceuticals developing both alpha and beta radionuclides to treat solid tumors

Long-acting endocrine peptide therapies to treat endocrine disorders, including hypoparathyroidism

A surgical robotic platform with wristed instruments for open microsurgery

Platform for digital quantification of proteins and nucleic acids to aid diagnosis and prognosis

Platform for mitochondrial genome editing to create hybrid seeds with dramatically higher crop yields

Cell-free biomanufacturing solutions for biologics, mRNA therapies, and vaccines

Structural biology platform to design small molecules therapies for cancer

Highly selective small molecules for autoimmune and other disorders

High-efficiency, low-cost benchtop system for single-cell analysis

DNA analysis in liquid biopsies to enable early detection of lung cancer

Tumor-infiltrating T-cell therapies to treat melanoma and other solid tumors

Targeted protein degraders for breast cancer, lung cancer, and other solid tumors

Platform for discovering and commercializing soil microbes to enable sustainable agriculture

Targeted antibody-drug conjugate therapies for solid tumors

Tests to identify bacteria causing blood infections and determine antibiotic susceptibility

Nonviral DNA-based gene delivery platform that aims to improve nuclear localization and gene expression

Small molecule that safely accelerates energy expenditure to treat obesity and cardiometabolic disorders

Next-gen engineered gene editing therapies based on synthetic CRISPR molecules

Precision diagnostics and phenotyping platforms for infectious diseases

Drug discovery platform using engineered complexes recapitulating native GPCR structure and function

Small molecule therapy that restores lung function in patients with cystic fibrosis

Integrated kidney care company focused on improving outcomes via high-touch patient management

Controlled-release intraocular drug delivery for patients with glaucoma undergoing cataract surgery

First-in-class antibodies capable of treating multiple rare diseases

Generative biology and chemistry platform to quickly and accurately design therapeutics

Topical eyedrop for decreasing progression of myopia in children

Selective cytokine therapeutics for cancer and inflammatory disease

Platform for creating precisely engineered T-cell receptors to create new cancer therapies

Patient-centric devices to enable painless remote blood sample collection

Precision bioseparation solutions to optimize filtration for drug manufacturing

Membership-based counseling practice designed around client needs

Targeted antibody-drug conjugate therapies for ovarian cancer and other solid tumors

Rationally designed molecular glue therapies for high-value disease targets

All-RNA gene writing platform to address severe genetic disorders

Needle-free vaccine patch technology

Comprehensive guideline-directed care for patients with heart failure

Platform for structure-based drug discovery to target difficult-to-drug proteins

Small molecule inhibitors for cancer that target a key tumor signaling pathway

Minimally invasive catheter to remove fluid from the lymphatic system to treat heart failure

Palforzia allergen powder to manage peanut allergy and Zenpep pancreatic enzyme replacement therapy

Potentially best-in-class anti-TSLP antibody therapy to treat respiratory and inflammatory conditions

Gene therapies for inner-ear disorders to restore, improve, and/or preserve hearing

Antimicrobials for non-tuberculous mycobacterial lung disease

Long-acting antibody therapies in atopic dermatitis and other inflammatory indications

Topical small molecule therapies for psoriasis and other immune-mediated skin diseases

Low-dose epinephrine nasal spray (Neffy) for severe allergic reactions

Targeted protein degraders to treat prostate cancer and other solid tumors

Transient conjugation platform to optimize therapeutic benefit in rare disease and cancer

Oral antiviral therapies to prevent and treat COVID-19 and other viral diseases

AAV gene therapies for serious rare neuromuscular diseases

Gene therapies for spinal muscular atrophy and other rare neurological genetic disorders

T-cell therapies to treat prostate cancer, other solid tumors, and inherited blood disorders

Small molecule therapies for migraine and other neurological diseases

Small molecule therapies for genomically defined cancers

Genetic medicines for thalassemia and other inherited blood disorders and rare diseases

Small molecule therapies for genomically defined cancers and rare diseases

Immune-stimulating antibody conjugates for HER2-expressing tumors and other cancers

Platform targeting extrachromosomal DNA to create new cancer therapies

Protein degraders targeting disease drivers for myeloma, lymphoma, and other cancers

Gene therapies for sickle cell disease, thalassemia, and other chronic blood disorders

Delivering life-changing therapeutics for rare diseases and cancer to Chinese markets

A chemotype evolution platform company developing therapies for metabolic disease and cancer

Pluripotent stem cell platform to create immune cell therapies for cancer

Oncolytic immunotherapies in bladder cancer

Long-acting antifungal and a platform for potent antibody fragment-drug conjugates

Inhaled levodopa (Inbrija) for the rapid-onset treatment of Parkinson's disease

Small molecule therapies to suppress cartilage growth to treat rare bone growth diseases

High-quality biosimilar therapeutics to help expand access to biologic medicines

Treatments for acute pain (Nucynta) and chronic pain (Xtampza ER)

T-cell-modulating therapies for atopic dermatitis and other chronic inflammatory diseases

Small molecule therapies for acromegaly and other rare endocrine diseases

Platform targeting DNA damage response with tumor cells to treat cancer

Best-in-class flow cytometry analyzers

Targeted therapies for pediatric low-grade glioma and other life-threatening diseases

Small molecule therapies that target the underlying cause of inherited diseases

Small molecule antagonists for psoriasis, other immune diseases, and cancer

Liver-targeted RNAi therapies for both rare and prevalent diseases

Liver-targeted gene therapies to treat hemophilia and other rare diseases

RNA therapies targeted to specific organs to treat ocular, neuromuscular, and CNS diseases

Gene silencing therapies targeted to muscle using antibody fragments to treat muscle dystrophies

Muscle-preserving small molecule therapies in patients with rare muscle disorders

Small molecule TTR stabilizer to treat transthyretin amyloidosis

Small molecule inhibitors and immune stimulators to treat Hepatitis D virus infection

Therapies targeting nerve transmission to treat pain, depression, and epilepsy

Antibody-drug conjugates to improve outcomes in hard-to-treat cancers

Bringing a portfolio of best-in-class therapies to Asian markets

End-to-end manufacturing services to accelerate gene therapy development and commercialization

Small molecule therapies to treat sickle cell disease and other hematologic disorders

Small molecule therapy to protect bone marrow and optimize chemotherapy in patients with cancer

Selective dismutase mimetics that can increase safety and efficacy of radiotherapies for cancer

Natural psychoactive drugs to treat psychiatric and neurological disorders

Small molecule therapy to stabilize red blood cells in patients with sickle cell disease

Gene editing therapies to correct the mutation in blood cells that causes sickle cell disease

Vaccine against norovirus, the most common viral cause of acute gastroenteritis

Vaccines for respiratory syncytial virus and other severe respiratory diseases

Small molecule therapies to treat sickle cell disease and beta-thalassemia

Complement-targeting antibodies to treat hidradenitis suppurativa and other inflammatory diseases

Antibody therapy platform leveraging single-domain protein engineering

Enzyme replacement therapies for rare diseases of abnormal mineralization

Peptide therapies to stimulate immune response in melanoma and other cancers

Therapies to reverse immune suppression to treat melanoma and other cancers

Immunotherapies capable of stimulating tumor-specific immune responses

Engineered T cells capable of recognizing and killing tumor cells to treat a broad range of cancers

Reformulated, longer-lasting steroid-based eye drop to treat dry eye disease

Small molecule protease inhibitors to treat hereditary angioedema and diabetic macular edema

Small molecule kinase inhibitors to treat genomically defined cancers

Patient-specific CAR-T cell therapies for multiple myeloma and T-cell lymphoma

Bringing clinically validated drugs to the Chinese market through strategic partnerships

Oral therapies to improve liver function in patients with rare liver disease

Microstent to manage glaucoma that can be inserted during cataract surgery

Long-acting bioresorbable implants to treat chronic rhinosinusitis

Screening platform to identify multispecific antibodies to treat solid tumors and autoimmune disease

Platform to identify new gene editing systems and create new genetic medicines

Aldosterone synthesis inhibitor to treat hypertension

mRNA medicines that instruct a patient’s own cells to produce therapeutic proteins

Non-invasive DNA tests for women's health and cancer detection

Protein-based immunotherapies to treat cancer and immune-mediated diseases

Engineering natural killer cells to treat blood cancers and solid tumors

Small molecule therapy targeting estrogen receptor to treat metastatic breast cancer

Gene therapies to treat lysosomal disorders and other rare inherited diseases

Solutions for infertility leveraging egg precursor cells

Immunomodulating protein therapies for autoimmune diseases

Hypoxia-modulating small molecule inhibitors to treat renal cancer and other solid tumors

Oligonucleotide delivery platform to treat muscular dystrophy and other neuromuscular diseases

Small molecule therapy to treat acid-related gastrointestinal disorders

Small molecule therapies targeting mutant p53 to treat genomically defined cancers

Radioactive isotope company with in-house manufacturing to help diagnose and treat cancer

Platform to create CAR-T cell therapies for cancer and in vivo gene editing therapies

Gene therapies to treat Parkinson's disease and other neurodegenerative disorders

Peptide-based therapeutics for blood disorders and inflammatory diseases

Antibody-drug conjugates and immunotherapies to treat non-small cell lung cancer and other cancers

Peptide therapies for myasthenia gravis and other complement-mediated diseases

Small molecule therapy for rare genetic mitochondrial diseases

First intraocular lens that optimizes vision following cataract surgery

Treatments for migraine and other debilitating conditions

Microbiome-modulating therapeutics for infectious and inflammatory diseases

Device using sound waves to break up calcified plaques associated with vascular disease

Small molecule therapies for myelofibrosis and other cancers

Targeted immunotherapies for cancer, viral infections, and other serious diseases

Gene therapies for Duchenne muscular dystrophy

Antibiotics to combat multi-drug resistant bacterial infections

RNA-based medicines that upregulate protein expression to treat severe disease

Synthetic DNA platform to optimize cytokine therapies for cancer and autoimmune disease

Implantable drug delivery system for bladder cancer and other bladder diseases

Curative gene therapies and cell regeneration treatments for heart disease

Small molecule inhibitor for chronic urticaria and other severe allergic diseases

Platform for discovering T-cell receptor and target pairs to develop new cancer therapies

Small molecule cancer therapies that address acquired resistance mutations

High-fidelity vaccines against pneumococcal infection and other bacterial infections

Protein therapies for metabolic and endocrine disorders

Single-course gene editing medicines for cardiovascular disease

Stem cell-derived cell replacement therapies for diabetes

Chemoproteomic platform to develop therapies for cancer

Hematopoietic stem cells to optimize stem cell transplants for cancer

Stereopure oligonucleotides for Huntington's disease and other serious genetic conditions

Conditionally activated cytokine therapies for cancer

Platform for tumor-selective activation of biologic therapies for cancer

Protein replacement therapy platform to treat complex rare diseases

Platform using an ion-trap technology to develop novel treatments for hyperkalemia